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Phospho-PTEN (Ser380) Recombinant Rabbit Monoclonal Antibody (PTENS380-NA9), APC

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Phospho-PTEN (Ser380) Recombinant Rabbit Monoclonal Antibody (PTENS380-NA9), APC

Product Details

MA5-37053

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PTENS380-NA9

Immunogen

A synthetic phospho peptide corresponding to residues surrounding Ser380 of human phospho PTEN.
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896988

Target Information

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Inositol polyphosphate 3-phosphatase; mitochondrial PTENalpha; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatidylinositol 3; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; pten tumor suppressor

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Gene Aliases: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MMAC1; PTEN; TEP1

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UniProt ID: (Mouse) O08586

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Entrez Gene ID: (Mouse) 19211

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Function(s)
magnesium ion binding phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding protein tyrosine/serine/threonine phosphatase activity anaphase-promoting complex binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity hydrolase activity phosphatase activity enzyme binding protein kinase binding PDZ domain binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity protein phosphatase
Process(es)
angiogenesis negative regulation of protein phosphorylation regulation of B cell apoptotic process protein dephosphorylation lipid metabolic process apoptotic process neuron-neuron synaptic transmission nervous system development synapse assembly central nervous system development heart development learning or memory memory locomotory behavior positive regulation of cell proliferation negative regulation of cell proliferation regulation of neuron projection development dephosphorylation cell migration dentate gyrus development central nervous system neuron axonogenesis negative regulation of cell migration neuron projection development negative regulation of myelination regulation of protein stability negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle regulation of synaptic transmission, GABAergic central nervous system myelin maintenance regulation of cellular component size regulation of myeloid cell apoptotic process multicellular organismal response to stress social behavior peptidyl-tyrosine dephosphorylation cellular response to decreased oxygen levels maternal behavior positive regulation of apoptotic process negative regulation of apoptotic process protein kinase B signaling endothelial cell migration locomotor rhythm negative regulation of cell size negative regulation of organ growth inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation platelet-derived growth factor receptor signaling pathway regulation of axon regeneration cardiac muscle tissue development forebrain morphogenesis brain morphogenesis negative regulation of epithelial cell proliferation negative regulation of phagocytosis negative regulation of axonogenesis protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity regulation of cell cycle negative regulation of focal adhesion assembly negative regulation of protein kinase B signaling rhythmic synaptic transmission canonical Wnt signaling pathway synapse maturation prepulse inhibition male mating behavior long-term synaptic potentiation long term synaptic depression prostate gland growth dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis positive regulation of ERK1 and ERK2 cascade cellular response to hypoxia negative regulation of ribosome biogenesis negative regulation of cell aging negative regulation of excitatory postsynaptic potential presynaptic membrane assembly postsynaptic density assembly positive regulation of ubiquitin protein ligase activity positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of G1/S transition of mitotic cell cycle positive regulation of excitatory postsynaptic potential negative regulation of synaptic vesicle clustering positive regulation of apoptotic signaling pathway
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