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Invitrogen
MHC Class I Monoclonal Antibody (IVA26), Alexa Fluor™ 488
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FIGURE: 1 / 2
MHC Class I Antibody (MA5-44137) in Flow
Separation of bovine lymphocytes stained using anti-bovine MHC Class I (IVA26) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-44137), concentration in sample 1 µg/mL (red-filled) from bovine lymphocytes stained using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 488 antibody (concentration in sample 1 µg/mL, black-dashed) in flow cytometry analysis (surface staining) of bovine peripheral whole blood.
Product Details
MA5-44137
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Bovine,
Human,
Mouse,
Sheep,
Pig,
Rabbit
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
IVA26
Immunogen
bovine lymphocytes
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Size-exclusion chromatography
Storage buffer
PBS
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope on MHC class I (alpha + beta2m chains) expressed in various animals.
Target Information
Like their mammalian counterparts, avian MHC Class I molecules, also known as B-F antigens, consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell surface glycoprotein; integral membrane protein; heavy chain; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA protein allele A25; HLA-A; HLA-A 2402; HLA-A*0201 alpha chain; human leukocyte antigen; HLA-A*0204; HLA-A*0207 alpha chain; human leukocyte antigen; HLA-A-0102 allele; HLA-A24AK; HLA-A25; human leukocyte antigen; Human leukocyte antigen A; leukocyte antigen class I-A; major histocompatibility complex class I A; MHC class I antigen; MHC class I antigen HLA-A heavy chain; MHC HLA-A cell surface antigen; MHC HLA-A10-alpha-2 chain precursor; MHC HLA-A2.4a chain; MHC HLA-A24 cell surface glycoprotein; ovar-MHCI-B564; ovar-MHCI-D5; ovar-MHCI-F12; unnamed protein product
Gene Aliases: HLA-A; HLAA; Ovar-I
UniProt ID: (Human) P04439
Entrez Gene ID: (Human) 3105, (Sheep) 101108963, (Sheep) 100171394
T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity
adaptive immune response
immune system process
T cell mediated cytotoxicity directed against tumor cell target
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
peptide antigen assembly with MHC class I protein complex
positive regulation of T cell cytokine production
immune response
detection of bacterium
antibacterial humoral response
antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of interferon-gamma production
CD8-positive, alpha-beta T cell activation
protection from natural killer cell mediated cytotoxicity
antigen processing and presentation of exogenous peptide antigen via MHC class I
innate immune response
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of CD8-positive, alpha-beta T cell proliferation
positive regulation of memory T cell activation
positive regulation of CD8-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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