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Invitrogen
MHC Class I Monoclonal Antibody (IVA26)
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FIGURE: 1 / 2
MHC Class I Antibody (MA5-44043) in Flow
Separation of bovine lymphocytes stained using anti-bovine MHC Class I (IVA26) purified Monoclonal antibody (Product # MA5-44043), concentration in sample 10 µg/mL, GAM APC (red-filled) from bovine lymphocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-44043
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Bovine,
Human,
Mouse,
Sheep,
Pig,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
IVA26
Immunogen
bovine lymphocytes
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope on MHC class I (alpha + beta2m chains) expressed in various animals.
Target Information
Like their mammalian counterparts, avian MHC Class I molecules, also known as B-F antigens, consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell surface glycoprotein; integral membrane protein; heavy chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA protein allele A25; HLA-A; HLA-A 2402; HLA-A*0201 alpha chain; human leukocyte antigen; HLA-A*0204; HLA-A*0207 alpha chain; human leukocyte antigen; HLA-A-0102 allele; HLA-A24AK; HLA-A25; human leukocyte antigen; leukocyte antigen class I-A; major histocompatibility complex class I A; MHC class I antigen HLA-A heavy chain; MHC HLA-A cell surface antigen; MHC HLA-A10-alpha-2 chain precursor; MHC HLA-A2.4a chain; MHC HLA-A24 cell surface glycoprotein; ovar-MHCI-B564; unnamed protein product
Gene Aliases: HLAA
UniProt ID: (Human) P04439
Entrez Gene ID: (Human) 3105, (Sheep) 100171394
T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity
T cell mediated cytotoxicity directed against tumor cell target
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of exogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
peptide antigen assembly with MHC class I protein complex
regulation of natural killer cell mediated immunity
positive regulation of T cell cytokine production
immune response
detection of bacterium
antibacterial humoral response
antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of interferon-gamma production
CD8-positive, alpha-beta T cell activation
protection from natural killer cell mediated cytotoxicity
antigen processing and presentation of exogenous peptide antigen via MHC class I
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of CD8-positive, alpha-beta T cell proliferation
positive regulation of memory T cell activation
positive regulation of CD8-positive, alpha-beta T cell activation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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