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Invitrogen

ATP7A Monoclonal Antibody (L60/4), PerCP

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ATP7A Monoclonal Antibody (L60/4), PerCP

Product Details

MA5-45520

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

L60/4

Immunogen

Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1
3D Epitope / Immunogen

Conjugate

PerCP PerCP PerCP

Excitation/Emission Max

482/675 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931974

Product Specific Information

1 µg/mL of MA5-45520 was sufficient for detection of Copper-transporting ATPase1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.|Detects approximately 180kDa in rat brain membrane preparations.

This antibody was formerly sold as clone S60-4.

Target Information

ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP 7A; ATP7A; ATPase, Cu++ transporting, alpha polypeptide; copper efflux transporter; copper pump 1; Cu++-transporting P-type ATPase; FLJ17790; MC 1; Menke; Menkes disease-associated protein; menkes disease-associated protein homolog; Menkes protein; Menkes syndrome; OHS; OTTHUMP00000062077; unnamed protein product; Wilson disease gene

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Gene Aliases: DSMAX; HMNX; MK; MNK; SMAX3

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UniProt ID: (Human) Q04656, (Mouse) Q64430, (Rat) P70705

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Entrez Gene ID: (Human) 538, (Mouse) 11977, (Rat) 24941

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Function(s)
nucleotide binding copper ion transmembrane transporter activity copper ion binding protein binding ATP binding ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism superoxide dismutase copper chaperone activity ATPase activity cation-transporting ATPase activity copper-dependent protein binding metal ion binding P-type monovalent copper transporter activity cuprous ion binding small GTPase binding chaperone binding
Process(es)
blood vessel development release of cytochrome c from mitochondria blood vessel remodeling regulation of oxidative phosphorylation catecholamine metabolic process cation transport copper ion transport cellular copper ion homeostasis mitochondrion organization locomotory behavior glycoprotein biosynthetic process response to manganese ion detoxification of copper ion regulation of gene expression positive regulation of lamellipodium assembly copper ion import peptidyl-lysine modification removal of superoxide radicals cerebellar Purkinje cell differentiation pyramidal neuron development central nervous system neuron development extracellular matrix organization collagen fibril organization hair follicle morphogenesis negative regulation of iron ion transmembrane transport cellular response to platelet-derived growth factor stimulus T-helper cell differentiation epinephrine metabolic process norepinephrine metabolic process dopamine metabolic process norepinephrine biosynthetic process serotonin metabolic process positive regulation of catalytic activity pigmentation negative regulation of neuron apoptotic process skin development positive regulation of cell size ATP metabolic process response to copper ion positive regulation of melanin biosynthetic process elastic fiber assembly lung alveolus development neuron projection morphogenesis dendrite morphogenesis positive regulation of epithelial cell proliferation cartilage development copper ion export cellular response to amino acid stimulus cellular response to copper ion positive regulation of superoxide dismutase activity positive regulation of response to wounding positive regulation of vascular associated smooth muscle cell migration regulation of cytochrome-c oxidase activity positive regulation of cytochrome-c oxidase activity in utero embryonic development liver development female pregnancy lactation response to iron(III) ion response to zinc ion response to lead ion cellular response to antibiotic cellular response to cadmium ion cellular response to cobalt ion cellular response to iron ion cellular response to lead ion cellular response to hypoxia
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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