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Invitrogen

NMDAR1 Monoclonal Antibody (N308/48), FITC

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NMDAR1 Monoclonal Antibody (N308/48), FITC

Product Details

MA5-45563

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N308/48

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932017

Product Specific Information

1 µg/mL of MA5-45563 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 105kDa.

This antibody was formerly sold as clone S308-48.

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; putative NMDtranscript(altAcc_e2); RP11-350O14.1

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Gene Aliases: DEE101; GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; hNR1; M100174; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding ligand-gated ion channel activity ligand-gated sodium channel activity glycine binding glutamate binding glutamate-gated calcium ion channel activity signaling receptor activity macromolecular complex binding metal ion binding glycine-gated cation channel activity ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity cation channel activity enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity receptor activity transmembrane signal receptor
Process(es)
ion transport cation transport chemical synaptic transmission brain development visual learning positive regulation of calcium ion transport into cytosol propylene metabolic process calcium-mediated signaling ion transmembrane transport ionotropic glutamate receptor signaling pathway sodium ion transmembrane transport regulation of membrane potential response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity protein heterotetramerization positive regulation of synaptic transmission, glutamatergic calcium ion homeostasis excitatory postsynaptic potential calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission positive regulation of reactive oxygen species biosynthetic process regulation of cation transmembrane transport cellular response to beta-amyloid response to glycine positive regulation of excitatory postsynaptic potential conditioned taste aversion startle response suckling behavior response to amphetamine calcium ion transport cellular calcium ion homeostasis respiratory gaseous exchange learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine sensory perception of pain pons maturation cerebral cortex development regulation of ion transmembrane transport social behavior synaptic transmission, glutamatergic positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis neuromuscular process protein tetramerization response to calcium ion regulation of synapse assembly prepulse inhibition male mating behavior response to fungicide cellular response to manganese ion transport
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