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Invitrogen

NMDAR1 Monoclonal Antibody (N308/48), PerCP

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NMDAR1 Monoclonal Antibody (N308/48), PerCP

Product Details

MA5-45564

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N308/48

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
3D Epitope / Immunogen

Conjugate

PerCP PerCP PerCP

Excitation/Emission Max

482/675 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932018

Product Specific Information

1 µg/mL of MA5-45564 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 105kDa.

This antibody was formerly sold as clone S308-48.

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Glun1r; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; putative NMDtranscript(altAcc_e2); RP11-350O14.1; unnamed protein product

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Gene Aliases: DEE101; GluN1; GluRdelta1; GluRzeta1; hNR1; M100174; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding ligand-gated ion channel activity ligand-gated sodium channel activity glycine binding glutamate binding transmitter-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity macromolecular complex binding glycine-gated cation channel activity ionotropic glutamate receptor activity receptor binding cation channel activity enzyme binding phosphatase binding voltage-gated cation channel activity glutamate receptor binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor binding
Process(es)
ion transport cation transport chemical synaptic transmission brain development visual learning positive regulation of calcium ion transport into cytosol propylene metabolic process calcium-mediated signaling ionotropic glutamate receptor signaling pathway sodium ion transmembrane transport regulation of membrane potential response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity protein heterotetramerization positive regulation of synaptic transmission, glutamatergic calcium ion homeostasis excitatory postsynaptic potential calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission positive regulation of reactive oxygen species biosynthetic process regulation of cation transmembrane transport cellular response to beta-amyloid response to glycine positive regulation of excitatory postsynaptic potential conditioned taste aversion response to hypoxia startle response suckling behavior response to amphetamine calcium ion transport cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning regulation of cell communication response to amine sensory perception of pain pons maturation hypothalamus development cerebral cortex development social behavior synaptic transmission, glutamatergic positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange regulation of long-term neuronal synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis regulation of synapse organization neuromuscular process positive regulation of mitochondrial calcium ion concentration response to calcium ion regulation of synapse assembly regulation of postsynaptic membrane potential prepulse inhibition male mating behavior response to fungicide protein-containing complex assembly cellular response to manganese ion regulation of presynaptic membrane potential chemical synaptic transmission, postsynaptic regulation of plasma membrane bounded cell projection organization positive regulation of Schwann cell migration positive regulation of dendritic spine maintenance response to glycoside protein localization to postsynaptic membrane cellular response to glycine rhythmic process
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