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Invitrogen

NMDAR2A Monoclonal Antibody (N327/95), PE

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NMDAR2A Monoclonal Antibody (N327/95), PE

Product Details

MA5-45603

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N327/95

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932057

Product Specific Information

1 µg/mL of MA5-45603 was sufficient for detection o GluN2A/NR2A in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 170kDa. Does not react with NR2B.

This antibody was formerly sold as clone S327-95.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA 2A; glutamate receptor; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; OTTHUMP00000160135; OTTHUMP00000174531; unnamed protein product

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Gene Aliases: EPND; FESD; GluN2A; GluRepsilon1; LKS; NMDAR2A; NR2A

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UniProt ID: (Human) Q12879, (Rat) Q00959, (Mouse) P35436

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Entrez Gene ID: (Human) 2903, (Rat) 24409, (Mouse) 14811

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity cation channel activity calcium channel activity protein binding zinc ion binding ligand-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity glutamate binding protein kinase binding voltage-gated cation channel activity glutamate receptor binding macromolecular complex binding calcium-dependent protein binding cell adhesion molecule binding ATPase binding scaffold protein binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential protein tyrosine kinase binding
Process(es)
action potential receptor recycling startle response response to amphetamine ion transport calcium ion transport positive regulation of cytosolic calcium ion concentration glutamate receptor signaling pathway chemical synaptic transmission learning or memory learning memory associative learning visual learning response to xenobiotic stimulus response to light stimulus response to wounding response to carbohydrate response to manganese ion response to lithium ion response to lead ion response to amine sensory perception of pain calcium-mediated signaling spinal cord development mesencephalic trigeminal nucleus development hippocampus development cerebral cortex development neurogenesis sleep auditory behavior regulation of ARF protein signal transduction directional locomotion multicellular organismal response to stress response to nicotine ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic sodium ion transmembrane transport locomotion negative regulation of protein catabolic process response to cocaine regulation of membrane potential dopamine metabolic process serotonin metabolic process positive regulation of apoptotic process response to ethanol regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission positive regulation of mitochondrial calcium ion concentration response to calcium ion response to methylmercury response to other organism positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation response to ammonium ion response to fungicide calcium ion transmembrane transport cellular response to amino acid stimulus cellular response to magnesium ion cellular response to manganese ion cellular response to zinc ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid positive regulation of protein targeting to membrane response to environmental enrichment dendritic spine organization positive regulation of inhibitory postsynaptic potential calcium ion transmembrane import into cytosol cation transmembrane transport modulation of excitatory postsynaptic potential regulation of presynaptic membrane potential neurotransmitter receptor transport, plasma membrane to endosome regulation of response to alcohol response to glycoside protein localization to postsynaptic membrane regulation of cation transmembrane transport cellular response to beta-amyloid response to hydrogen sulfide cellular response to glycine conditioned place preference regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential brain development excitatory chemical synaptic transmission locomotory behavior rhythmic process neuromuscular process
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