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Invitrogen

GluR1 Monoclonal Antibody (N355/1), FITC

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GluR1 Monoclonal Antibody (N355/1), FITC

Product Details

MA5-45628

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N355/1

Immunogen

Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.09mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932082

Product Specific Information

1 µg/mL of MA5-45628 was sufficient for detection of GluA1/GluR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 100kDa. Does not cross-react with GluR2.

This antibody was formerly sold as clone S355-1.

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AI853806; AMPA 1; AMPA receptor subunit GluA1; AMPA-selective glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1; unnamed protein product

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Gene Aliases: 2900051M01Rik; Glr-1; Glr1; GLUA1; GLUH1; Glur-1; GluR-A; gluR-K1; GLUR1; GLURA; GRIA1; HBGR1; HIPA1; MRD67; MRT76

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UniProt ID: (Human) P42261, (Rat) P19490, (Mouse) P23818

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Entrez Gene ID: (Human) 2890, (Rat) 50592, (Mouse) 14799

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Function(s)
beta-amyloid binding G-protein alpha-subunit binding ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding adenylate cyclase binding ligand-gated ion channel activity immunoglobulin binding protein kinase binding protein domain specific binding glutamate-gated calcium ion channel activity PDZ domain binding small GTPase binding myosin V binding G-protein beta-subunit binding beta-2 adrenergic receptor binding glutamate receptor binding signaling receptor activity identical protein binding protein kinase A binding peptide hormone receptor binding scaffold protein binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential extracellular-glutamate-gated ion channel activity protein homodimerization activity receptor activity transmembrane signal receptor
Process(es)
regulation of receptor recycling ion transport signal transduction chemical synaptic transmission synapse assembly long-term memory response to xenobiotic stimulus response to toxic substance response to sucrose response to lithium ion positive regulation of gene expression neuronal action potential calcium-mediated signaling spinal cord development cerebral cortex development receptor internalization response to nutrient levels response to estradiol ion transmembrane transport regulation of ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic response to cocaine response to morphine response to peptide hormone response to ethanol positive regulation of membrane potential response to arsenic-containing substance regulation of synaptic plasticity behavioral response to pain modulation of synaptic transmission positive regulation of synaptic transmission response to electrical stimulus regulation of postsynaptic membrane potential long-term synaptic potentiation long term synaptic depression response to fungicide cellular response to amino acid stimulus cellular response to ammonium ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to amine stimulus positive regulation of locomotion involved in locomotory behavior regulation of presynaptic membrane potential cellular response to L-glutamate cellular response to brain-derived neurotrophic factor stimulus conditioned place preference response to psychosocial stress positive regulation of excitatory postsynaptic potential response to organic cyclic compound response to drug cellular response to organic cyclic compound transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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