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Invitrogen

LRRK2 Monoclonal Antibody (N231B/34), APC

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LRRK2 Monoclonal Antibody (N231B/34), APC

Product Details

MA5-45641

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N231B/34

Immunogen

Fusion protein amino acids 841-960 of human LRRK2.
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932095

Product Specific Information

81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.

10 µg/mL of MA5-45641 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects >200kDa.

This antibody was formerly sold as clone S231B-34.

Target Information

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: augmented in rheumatoid arthritis 17; BC 300-268; DKFZp434H2111; FLJ45829; LRR kinase 2; LRRK 2; LRRK-2

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Gene Aliases: AURA17; DARDARIN; PARK8; RIPK7; ROCO2

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UniProt ID: (Human) Q5S007

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Entrez Gene ID: (Human) 120892, (Rat) 300160

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Function(s)
SNARE binding magnesium ion binding actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity GTPase activator activity protein binding ATP binding GTP binding microtubule binding tubulin binding kinase activity syntaxin-1 binding receptor signaling complex scaffold activity clathrin binding small GTPase binding GTP-dependent protein kinase activity peroxidase inhibitor activity co-receptor binding identical protein binding protein homodimerization activity ion channel binding protein kinase A binding protein serine kinase activity beta-catenin destruction complex binding nucleotide binding
Process(es)
MAPK cascade protein phosphorylation protein import into nucleus endocytosis response to oxidative stress mitochondrion organization endoplasmic reticulum organization Golgi organization lysosome organization cell surface receptor signaling pathway JNK cascade Rho protein signal transduction spermatogenesis neuromuscular junction development protein localization determination of adult lifespan cellular response to starvation anatomical structure morphogenesis negative regulation of signal transduction regulation of gene expression regulation of autophagy positive regulation of autophagy negative regulation of protein processing negative regulation of neuron projection development regulation of neuron maturation vesicle-mediated transport negative regulation of macroautophagy calcium-mediated signaling striatum development olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb regulation of proteolysis neuron differentiation regulation of cell projection organization positive regulation of protein ubiquitination regulation of protein stability positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production negative regulation of GTPase activity cellular response to oxidative stress cellular response to reactive oxygen species regulation of SNARE complex assembly intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of locomotion regulation of membrane potential positive regulation of programmed cell death positive regulation of MAPK cascade negative regulation of Notch signaling pathway GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria animal organ development neuron projection morphogenesis modulation of synaptic transmission regulation of multicellular organismal process positive regulation of protein metabolic process mitochondrion localization regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of vesicle-mediated transport regulation of ER to Golgi vesicle-mediated transport regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis protein localization to endoplasmic reticulum exit site cellular response to manganese ion positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential neuron projection arborization regulation of cAMP/PKA signal transduction regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of intracellular signal transduction regulation of neuroblast proliferation regulation of synaptic vesicle transport negative regulation of autophagosome assembly cellular response to dopamine negative regulation of establishment of protein localization to mitochondrion positive regulation of microglial cell activation cellular response to curcumin Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis regulation of reactive oxygen species metabolic process canonical Wnt signaling pathway protein localization to mitochondrion regulation of mitochondrial fission negative regulation of late endosome to lysosome transport negative regulation of motile cilium assembly
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