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Invitrogen
HDAC1 Monoclonal Antibody (10E2), FITC
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Product Details
MA5-46593
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10E2
Immunogen
Synthetic peptide: EEKPEAKGVKEEVKLA, corresponding to C terminal amino acids 467-482 of Human and mouse HDAC1
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686H12203; HD1; HDAC1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein deacylase HDAC1; protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; unnamed protein product
Gene Aliases: GON-10; HD1; HDAC1; Hdac1-ps; KDAC1; MommeD5; RPD3; RPD3L1
UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4
Entrez Gene ID: (Human) 3065, (Mouse) 433759, (Rat) 297893
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcription corepressor binding
p53 binding
DNA binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
enzyme binding
nucleosomal DNA binding
protein deacetylase activity
Krueppel-associated box domain binding
histone deacetylase binding
metal ion binding
NF-kappaB binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
protein lysine delactylase activity
promoter-specific chromatin binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
deacetylase activity
histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
protein complex binding
activating transcription factor binding
histone deacetylase activity (H4-K16 specific)
transcription regulatory region DNA binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
protein N-terminus binding
repressing transcription factor binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein deacetylation
endoderm development
circadian rhythm
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermal cell differentiation
negative regulation of gene expression
positive regulation of receptor biosynthetic process
chromatin modification
histone deacetylation
hippocampus development
neuron differentiation
positive regulation of interleukin-1 production
positive regulation of tumor necrosis factor production
circadian regulation of gene expression
cellular response to oxidative stress
odontogenesis of dentin-containing tooth
positive regulation of tyrosine phosphorylation of Stat3 protein
embryonic digit morphogenesis
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
negative regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
rhythmic process
positive regulation of oligodendrocyte differentiation
negative regulation of androgen receptor signaling pathway
hair follicle placode formation
eyelid development in camera-type eye
fungiform papilla formation
histone H3 deacetylation
histone H4 deacetylation
negative regulation of canonical Wnt signaling pathway
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of type B pancreatic cell apoptotic process
negative regulation of peptidyl-lysine acetylation
negative regulation of intrinsic apoptotic signaling pathway
chromatin organization
chromatin remodeling
methylation-dependent chromatin silencing
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of myotube differentiation
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
heterochromatin assembly
positive regulation of intracellular estrogen receptor signaling pathway
cellular response to platelet-derived growth factor stimulus
regulation of cell fate specification
negative regulation of gene expression, epigenetic
positive regulation of smooth muscle cell proliferation
oligodendrocyte differentiation
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
regulation of stem cell differentiation
response to caffeine
response to lipopolysaccharide
response to drug
response to hyperoxia
cellular response to tumor necrosis factor
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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