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Invitrogen
ITPRIPL1 Recombinant Human Monoclonal Antibody (6D11)
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Product Details
MA5-60825
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Human
/ IgG4SP
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
6D11
Immunogen
Recombinant Human ITPRIPL1 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DANGER family member 1B; inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
Gene Aliases: D1B; ITPRIPL1; KIAA1754L
UniProt ID: (Human) Q6GPH6
Entrez Gene ID: (Human) 150771
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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