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Invitrogen
CD21 Monoclonal Antibody (LT21), PE-Cyanine7
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FIGURE: 1 / 2
CD21 Antibody (MA562243) in Flow
Flow cytometry (surface staining) of CD21 in human peripheral whole blood. Samples were stained with CD21 monoclonal antibody (Product # MA562243) using a dilution of 4 µL reagent/100 µL of peripheral whole blood. Separation of human CD21 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed).
Product Details
MA562243
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Pig
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
LT21
Immunogen
IM9 human B-lymphoblastoid cell line.
Conjugate
Excitation/Emission Max
569/780 nm
View spectra
Form
Liquid
Concentration
0.03 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD21; Complement C3d receptor; Complement C3d receptor (C3DR); complement component (3b/4b) receptor 1 (Knops blood group); complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement component receptor 2; complement receptor 1 long isoform; Complement receptor type 2; Complement Receptor type 2 (CR2); Cr2; CR2 precursor; CR2/CD21/C3d/Epstein-Barr virus receptor precursor; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; unnamed protein product
Gene Aliases: C3DR; CD21; CR; CR1; CR2; CVID7; SLEB9
UniProt ID: (Human) P20023
Entrez Gene ID: (Dog) 490269, (Human) 1380, (Bovine) 407126
immune system process
complement receptor mediated signaling pathway
T cell mediated immunity
immune response
complement activation, alternative pathway
complement activation, classical pathway
B cell differentiation
B cell proliferation
B cell activation
innate immune response
negative regulation of complement activation, classical pathway
viral entry into host cell
type I interferon signaling pathway
antiviral innate immune response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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