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Invitrogen

Syk Monoclonal Antibody (SYK-01), Alexa Fluor™ 647

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Syk Monoclonal Antibody (SYK-01), Alexa Fluor™ 647

Product Details

MA574329

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SYK-01

Immunogen

Recombinant fragment (aa 5-360) of human Syk.
3D Epitope / Immunogen

Conjugate

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

Excitation/Emission Max

650/671 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; SP1; spleen tyrosine kinase; syk signaling; tyrosine-kinase syk; unnamed protein product

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Gene Aliases: IMD82; p72-Syk; p72syk; Sykb

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UniProt ID: (Human) P43405, (Mouse) P48025, (Rat) Q64725

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Entrez Gene ID: (Human) 6850, (Mouse) 20963, (Rat) 25155

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Function(s)
phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding integrin binding protein binding ATP binding interleukin-15 receptor binding kinase activity protein kinase binding phosphatase binding Toll-like receptor binding SH2 domain binding phospholipase binding scaffold protein binding protein domain specific binding ubiquitin protein ligase binding immunoglobulin receptor binding
Process(es)
cell activation lymph vessel development positive regulation of receptor internalization stimulatory C-type lectin receptor signaling pathway adaptive immune response macrophage activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response serotonin secretion by platelet cell surface pattern recognition receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter protein phosphorylation protein import into nucleus leukocyte cell-cell adhesion integrin-mediated signaling pathway organ morphogenesis regulation of platelet activation regulation of tumor necrosis factor-mediated signaling pathway peptidyl-tyrosine phosphorylation platelet activation neutrophil chemotaxis positive regulation of protein complex assembly receptor internalization positive regulation of type I interferon production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production regulation of superoxide anion generation positive regulation of superoxide anion generation positive regulation of cell adhesion mediated by integrin positive regulation of toll-like receptor 9 signaling pathway intracellular signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis interleukin-3-mediated signaling pathway defense response to bacterium regulation of neutrophil degranulation innate immune response positive regulation of B cell differentiation positive regulation of lymphocyte differentiation positive regulation of bone resorption blood vessel morphogenesis positive regulation of inflammatory response regulation of phagocytosis regulation of immune response B cell receptor signaling pathway leukocyte migration regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin cellular response to lipid cellular response to low-density lipoprotein particle stimulus positive regulation of monocyte chemotactic protein-1 production regulation of arachidonic acid secretion regulation of platelet aggregation apoptotic signaling pathway beta-amyloid clearance positive regulation of cold-induced thermogenesis positive regulation of cGAS/STING signaling pathway positive regulation of TORC1 signaling cellular response to beta-amyloid cellular response to lectin autophagosome assembly positive regulation of cytokine production serotonin secretion cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway G-protein coupled receptor signaling pathway negative regulation of autophagy positive regulation of autophagy peptidyl-serine phosphorylation leukotriene biosynthetic process cellular response to nutrient levels positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-3 production collagen-activated tyrosine kinase receptor signaling pathway TORC1 signaling positive regulation of mast cell degranulation beta selection positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of gamma-delta T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling antigen receptor-mediated signaling pathway negative regulation of TORC1 signaling
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