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Proteintech
MASP1 Polyclonal Antibody
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Product Details
21837-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MASP1 Fusion Protein Ag16432 (379-728 aa encoded by BC106945)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TFSTRNNLT TYKSEIKYSC QEPYYKMLNN NTGIYTCSAQ GVWMNKVLGR SLPTCLPECG QPSRSLPSLV KRIIGGRNAE PGLFPWQALI VVEDTSRVPN DKWFGSGALL SASWILTAAH VLRSQRRDTT VIPVSKEHVT VYLGLHDVRD KSGAVNSSAA RVVLHPDFNI QNYNHDIALV QLQEPVPLGP HVMPVCLPRL EPEGPAPHML GLVAGWGISN PNVTVDEIIS SGTRTLSDVL QYVKLPVVPH AECKTSYESR SGNYSVTENM FCAGYYEGGK DTCLGDSGGA FVIFDDLSQR WVVQGLVSWG GPEECGSKQV YGVYTKVSNY VDWVWEQMGL PQSVVEPQVE R (379-728 aa encoded by BC106945)
Target Information
MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C4/C2 activating component of Ra-reactive factor; complement factor MASP-3; Complement-activating component of Ra-reactive factor; mannan binding lectin serine peptidase 1; mannan-binding; Mannan-binding lectin serine protease 1; mannose-associated serine protease 1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; MASP-1; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; unnamed protein product
Gene Aliases: 3MC1; CRARF; CRARF1; MAP-1; MAP1; MAp44; MASP; MASP-3; MASP1; MASP3; PRSS5; RaRF
UniProt ID: (Human) P48740
Entrez Gene ID: (Human) 5648
complement activation, lectin pathway
activation of membrane attack complex
immune system process
proteolysis
complement activation
complement activation, alternative pathway
opsonization
zymogen activation
killing of cells of other organism
innate immune response
negative regulation of complement activation
protein maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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