MASP1 Antibodies

Target Information

MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

Synonyms

3MC1; AW048060; C4/C2 activating component of Ra-reactive factor; CCPII; Complement factor MASP-3; complement-activating component of Ra-reactive factor; Crarf; CRARF1; mannan binding lectin serine peptidase 1; mannan-binding; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); mannan-binding lectin serine protease 1; Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain; Mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; MAP1; MAp44; MASP; MASP1; MASP-1; Masp1/3; MASP3; PRSS5; Ra-reactive factor serine protease p100; raRF; Serine protease 5; serine protease MASP1