Immunofluorescent analysis of MTO1 showing staining in the cytoplasm of HeLa cells. HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37°C for 30 min and stained using a MTO1 polyclonal antibody (Product # PA5-35933) diluted at 1:500. Blue: Hoechst 33342 staining.
|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 99 and 692 of MTO1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
CGI-02; COXPD10; homolog of yeast Mto1; mitochondrial MTO1-3; mitochondrial translation optimization 1 homolog; mitochondrial translation optimization 1 homolog S. cerevisiae; protein MTO1 homolog, mitochondrial
2310039H01Rik; 5730419A02Rik; CGI-02; COXPD10; MTO1