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Proteintech
NEIL1 Polyclonal Antibody
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Product Details
12145-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NEIL1 Fusion Protein Ag2793 (1-390 aa encoded by BC010876)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPEGPELHL ASQFVNEACR ALVFGGCVEK SSVSRNPEVP FESSAYRISA SARGKELRLI LSPLPGAQPQ QEPLALVFRF GMSGSFQLVP REELPRHAHL RFYTAPPGPR LALCFVDIRR FGRWDLGGKW QPGRGPCVLQ EYQQFRENVL RNLADKAFDR PICEALLDQR FFNGIGNYLR AEILYRLKIP PFEKARSVLE ALQQHRPSPE LTLSQKIRTK LQNPDLLELC HSVPKEVVQL GGRGYGSESG EEDFAAFRAW LRCYGMPGMS SLQDRHGRTI WFQGDPGPLA PKGRKSRKKK SKATQLSPED RVEDALPPSK APSRTRRAKR DLPKRTATQR PEGTSLQQDP EAPTVPKKGR RKGRQAASGH CRPRKVKADI PSLEPEGTSA S (1-390 aa encoded by BC010876)
Target Information
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease 8-like 1; endonuclease VIII; Endonuclease VIII-like 1; FLJ22402; FPG1; NEH1; nei endonuclease VIII-like 1; Nei homolog 1; Nei-like protein 1; unnamed protein product
Gene Aliases: 2810450N13Rik; FPG1; hFPG1; NEI1; NEIL1
UniProt ID: (Human) Q96FI4, (Mouse) Q8K4Q6
Entrez Gene ID: (Human) 79661, (Rat) 367090, (Mouse) 72774
nucleic acid binding
DNA binding
damaged DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
zinc ion binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
lyase activity
DNA N-glycosylase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
protein C-terminus binding
purine-specific mismatch base pair DNA N-glycosylase activity
uracil DNA N-glycosylase activity
single-strand selective uracil DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA glycosylase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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