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NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
2810450N13Rik; DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; endonuclease 8-like 1; endonuclease VIII; endonuclease VIII-like 1; FLJ22402; FPG1; hFPG1; NEH1; nei endonuclease VIII-like 1; nei endonuclease VIII-like 1 (E. coli); nei homolog 1; nei like DNA glycosylase 1; Nei1; NEIL1; nei-like DNA glycosylase 1; nei-like protein 1
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