Keep as concentrated solution.
Predicted reactivity: Mouse (87%), Rat (87%), Bovine (91%).
Positive Control: 293T, 293T nuclear extract, NEIL1-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
Protein Aliases: DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease 8-like 1; endonuclease VIII; Endonuclease VIII-like 1; FLJ22402; FPG1; NEH1; nei endonuclease VIII-like 1; Nei homolog 1; nei-like DNA glycosylase 1; Nei-like protein 1
Gene Aliases: FPG1; hFPG1; NEI1; NEIL1
UniProt ID: (Human) Q96FI4
Entrez Gene ID: (Human) 79661