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Product Details
12970-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OPRL1 Fusion Protein Ag4079 (71-370 aa encoded by BC038433)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LVMYVILRH TKMKTATNIY IFNLALADTL VLLTLPFQGT DILLGFWPFG NALCKTVIAI DYYNMFTSTF TLTAMSVDRY VAICHPIRAL DVRTSSKAQA VNVAIWALAS VVGVPVAIMG SAQVEDEEIE CLVEIPTPQD YWGPVFAICI FLFSFIVPVL VISVCYSLMI RRLRGVRLLS GSREKDRNLR RITRLVLVVV AVFVGCWTPV QVFVLAQGLG VQPSSETAVA ILRFCTALGY VNSCLNPILY AFLDENFKAC FRKFCCASAL RRDVQVSDRV RSIAKDVALA CKTSETVPRP A (71-370 aa encoded by BC038433)
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: K3 opiate receptor; Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; LC132 Receptor-Like; N/OFQ receptor; Nociceptin receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; opioid receptor-like 1; OPPRL1; ORGC; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
Gene Aliases: KOR-3; KOR3; LC132; MOR-C; morc; NOCIR; NOP; NOPr; OFQR; OOR; Oprl; OPRL1; ORGC; ORL1; XOR1
UniProt ID: (Human) P41146, (Mouse) Q9QUT5, (Rat) P35370
Entrez Gene ID: (Human) 4987, (Mouse) 18389, (Rat) 29256
positive regulation of protein phosphorylation
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
sensory perception of pain
negative regulation of cAMP biosynthetic process
response to estradiol
positive regulation of urine volume
opioid receptor signaling pathway
eating behavior
estrous cycle
negative regulation of blood pressure
positive regulation of gastric acid secretion
negative regulation of voltage-gated calcium channel activity
positive regulation of sensory perception of pain
regulation of locomotor rhythm
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
behavior
regulation of cAMP biosynthetic process
regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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