OPRL1 Antibodies

Target Information

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Synonyms

K3 opiate receptor; kappa3-related opioid receptor; kappa-type 3 opioid receptor; KOR3; KOR-3; LC132; LC132 Receptor-Like; morc; MOR-C; N/OFQ receptor; nociceptin receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; NOCIR; nop; NOPr; OFQR; OOR; opiate receptor-like 1; opioid receptor-like 1; opioid receptor-like protein Zf-orl; opioid related nociceptin receptor 1; opioid-receptor-like protein; OPPRL1; oprl; Oprl1; ORGC; ORL1; orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR; XOR1