Positive Samples: K-562, SW620, NCI-H460, U-87MG; Cellular Location: Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5 and apos;-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
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Protein Aliases: K3 opiate receptor; Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; N/OFQ receptor; Nociceptin receptor; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; ORGC; Orphanin FQ receptor
Gene Aliases: KOR-3; KOR3; LC132; MOR-C; morc; NOCIR; NOP; NOPr; OOR; Oprl; OPRL1; ORGC; ORL1; XOR1