This target displays homology in the following species: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
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Protein Aliases: Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; LC132 Receptor-Like; Nociceptin receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; OPPRL1; Orphanin FQ receptor
Gene Aliases: KOR-3; NOCIR; NOP; NOPr; OOR; OPRL1; ORL1
UniProt ID: (Human) P41146
Entrez Gene ID: (Human) 4987