Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: K3 opiate receptor; Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; N/OFQ receptor; Nociceptin Receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; opioid receptor-like 1; ORGC; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
Gene Aliases: KOR-3; KOR3; LC132; MOR-C; morc; NOCIR; NOP; NOPr; OFQR; OOR; Oprl; OPRL1; ORGC; ORL1; XOR1