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GBB1 Polyclonal Antibody
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Product Details
OSG00020W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the internal region of human GBB1 (Transducin beta chain 1, GNB1, Guanine nucleotide binding protein subunit beta-1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
Specificity of this antibody: GBB1.
Target Information
Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta subunit, signal-transducing proteins GS/GI; G protein beta 1; gbb1; GNB1; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein beta 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; heterotrimeric guanine nucleotide-binding protein 2A; T beta; testicular tissue protein Li 72; Transducin beta chain 1; transducin beta-1 subunit; unnamed protein product
Gene Aliases: AA409223; C77571; Gnb-1; GNB1; HG2A; MDS; MRD42
UniProt ID: (Human) P62873, (Mouse) P62874, (Rat) P54311
Entrez Gene ID: (Human) 2782, (Mouse) 14688, (Rat) 24400
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
Ras protein signal transduction
cell proliferation
sensory perception of taste
retina development in camera-type eye
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
positive regulation of cytosolic calcium ion concentration
phototransduction, visible light
cardiac muscle cell apoptotic process
cellular response to hypoxia
metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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