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Proteintech
PARN Polyclonal Antibody
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Product Details
13799-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PARN Fusion Protein Ag4774 (1-347 aa encoded by BC050029)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEIIRSNFK SNLHKVYQAI EEADFFAIDG EFSGISDGPS VSALTNGFDT PEERYQKLKK HSMDFLLFQF GLCTFKYDYT DSKYITKSFN FYVFPKPFNR SSPDVKFVCQ SSSIDFLASQ GFDFNKVFRN GIPYLNQEEE RQLREQYDEK RSQANGAGAL SYVSPNTSKC PVTIPEDQKK FIDQVVEKIE DLLQSEENKN LDLEPCTGFQ RKLIYQTLSW KYPKGIHVET LETEKKERYI VISKVDEEER KRREQQKHAK EQEELNDAVG FSRVIHAIAN SGKLVIGHNM LLDVMHTVHQ FYCPLPADLS EFKEMTTCVF PRLLDTKLMA STQPFKDIIN NTSLAELE (1-347 aa encoded by BC050029)
Target Information
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deadenylating nuclease; Deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); Poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease; unnamed protein product
Gene Aliases: 1200003I18Rik; DAN; DKCB6; PARN; PFBMFT4; RGD1565449
UniProt ID: (Human) O95453, (Mouse) Q8VDG3
Entrez Gene ID: (Human) 5073, (Mouse) 74108, (Rat) 360464
3'-5'-exoribonuclease activity
nucleic acid binding
RNA binding
mRNA 3'-UTR binding
nuclease activity
exonuclease activity
poly(A)-specific ribonuclease activity
protein binding
hydrolase activity
protein kinase binding
cation binding
metal ion binding
telomerase RNA binding
nucleotide binding
poly(A) RNA binding
mRNA polyadenylation factor
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA poly(A) tail shortening
box H/ACA snoRNA 3'-end processing
RNA catabolic process
mRNA catabolic process
female gamete generation
RNA modification
miRNA catabolic process
positive regulation of macromolecule metabolic process
negative regulation of macromolecule metabolic process
positive regulation of telomere maintenance via telomerase
regulation of RNA stability
positive regulation of nucleobase-containing compound metabolic process
polyadenylation-dependent snoRNA 3'-end processing
telomerase RNA stabilization
lncRNA processing
regulation of telomerase RNA localization to Cajal body
priRNA 3'-end processing
siRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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