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Invitrogen
PBK Polyclonal Antibody
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Product Details
PA5-84023
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PBK. Recombinant protein control fragment (Product #RP-104911).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ISNFKTPSKL SEKKKSVLCS TPTINIPASP FMQKLGFGTG VNVYLMKRSP RGLSHSPWAV KKINPICNDH YRSVYQKRLM DEAKILKSLH HPNIVGYRAF TEANDGSLCL AMEYGGEKSL NDLIEERYKA SQD
Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 84%.
Target Information
PBK (TOPK) is a serine/threonine kinase that is related to the dual specific mitogen-activated protein kinase (MAPKK). The kinase is up-regulated in a variety of hematological malignancies, participates in activating lymphoid cells, and supports testicular function (spermatogenesis). Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 84; CT84; epididymis luminal protein 164; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PBK; serine/threonine protein kinase; PDZ-binding kinase; serine/threonine protein kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; unnamed protein product
Gene Aliases: CT84; HEL164; Nori-3; PBK; SPK; TOPK
UniProt ID: (Human) Q96KB5
Entrez Gene ID: (Human) 55872
mitotic cell cycle
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of stress-activated MAPK cascade
cellular response to UV
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of inflammatory response
stress-activated MAPK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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