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Invitrogen
PDCD5 Polyclonal Antibody
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Product Details
PA5-114769
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PDCD5(Accession O14737), corresponding to amino acid residues E94-Y125.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PDCD5.
Target Information
Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein; PDCD5; Programmed cell death protein 5; Protein TFAR19; TF-1 cell apoptosis-related protein 19; TF1 cell apoptosis-related gene 19; TFAR19 novel apoptosis-related; unnamed protein product
Gene Aliases: 2200003D22Rik; AA408513; PDCD5; TFAR19
UniProt ID: (Human) O14737, (Mouse) P56812
Entrez Gene ID: (Human) 9141, (Mouse) 56330
apoptotic process
positive regulation of gene expression
regulation of apoptotic process
positive regulation of apoptotic process
cellular response to transforming growth factor beta stimulus
negative regulation of protein folding
negative regulation of cell proliferation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of release of cytochrome c from mitochondria
positive regulation of protein import into mitochondrial outer membrane
negative regulation of chaperone-mediated protein folding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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