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Invitrogen
PDCD6 Polyclonal Antibody
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FIGURE: 1 / 2
PDCD6 Antibody (PA5-110085) in WB
Western blot analysis of PDCD6 in extracts from wild type (WT) and PDCD6 knockout (KO) 293T(KO) cells. Samples were incubated with PDCD6 Polyclonal antibody (Product # PA5-110085) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-110085
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human PDCD6 (NP_037364.1).
Conjugate
Form
Liquid
Concentration
0.90 mg/mL
Amount
90 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V
Target Information
An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALG-2; ALG-257; Apoptosis-linked gene 2 protein; Apoptosis-linked gene 2 protein homolog; PMP41; probable calcium-binding protein ALG-2; Programmed cell death protein 6; unnamed protein product
Gene Aliases: ALG-2; ALG2; AV299538; MA-3; PDCD6; PEF1B; PS2
UniProt ID: (Human) O75340, (Rat) G3V7W1, (Mouse) Q545I0
Entrez Gene ID: (Human) 10016, (Rat) 308061, (Mouse) 18570
magnesium ion binding
calcium ion binding
protein binding
protein binding, bridging
identical protein binding
protein homodimerization activity
protein anchor
metal ion binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
protein binding, bridging involved in substrate recognition for ubiquitination
calcium-dependent cysteine-type endopeptidase activity
binding, bridging
actin or actin-binding cytoskeletal protein
angiogenesis
positive regulation of endothelial cell proliferation
intracellular protein transport
ER to Golgi vesicle-mediated transport
apoptotic process
positive regulation of endothelial cell migration
neural crest formation
neural crest cell development
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
cellular response to heat
vascular endothelial growth factor receptor-2 signaling pathway
positive regulation of apoptotic process
positive regulation of angiogenesis
COPII vesicle coating
response to calcium ion
negative regulation of protein kinase B signaling
apoptotic signaling pathway
positive regulation of protein monoubiquitination
proteolysis
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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