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Proteintech
CD314 Monoclonal Antibody (1D11), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PE-65188100TEST
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1D11
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
10 µL/Test
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: killer cell lectin-like receptor subfamily K, member 1; natural killer cell receptor; NK cell receptor D; NKG2-D-activating NK receptor; unnamed protein product
Gene Aliases: CD314; D12S2489E; KLR; NKG2-D; NKG2D
UniProt ID: (Human) P26718
Entrez Gene ID: (Human) 22914
defense response
signal transduction
natural killer cell activation
T cell costimulation
negative regulation of GTPase activity
natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of multicellular organismal process
response to other organism
negative regulation of natural killer cell chemotaxis
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