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Proteintech
PHLPPL Polyclonal Antibody
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Product Details
25244-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHLPPL Fusion Protein Ag19000 (575-781 aa encoded by BC129927)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LDLQHNALT RLPDTLFSKA LNLRYLNASA NSLESLPSAC TGEESLSMLQ LLYLTNNLLT DQCIPVLVGH LHLRILHLAN NQLQTFPASK LNKLEQLEEL NLSGNKLKTI PTTIANCKRL HTLVAHSNNI SIFPEILQLP QIQFVDLSCN DLTEILIPEA LPATLQDLDL TGNTNLVLEH KTLDIFSHIT TLKIDQKPLP TTDSTVTS (575-781 aa encoded by BC129927)
Target Information
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GTPase activating protein and VPS9 domains 1; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; protein phosphatase, Mg2+/Mn2+ dependent 3B; unnamed protein product
Gene Aliases: AI481772; C130044A18Rik; KIAA0931; PHLPP2; PHLPPL; PPM3B; RGD1562857
UniProt ID: (Human) Q6ZVD8, (Mouse) Q8BXA7
Entrez Gene ID: (Human) 23035, (Mouse) 244650, (Rat) 498949
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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