PHLPP2 Antibodies

Antibodies that detect PHLPP2 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target PHLPP2 in Human, Mouse and Rat samples. Our PHLPP2 polyclonal antibodies are developed... Antibodies that detect PHLPP2 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target PHLPP2 in Human, Mouse and Rat samples. Our PHLPP2 polyclonal antibodies are developed in Rabbit and Goat. Find the... Antibodies that detect PHLPP2 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target PHLPP2 in Human, Mouse and Rat samples. Our PHLPP2 polyclonal antibodies are developed in Rabbit and Goat. Find the PHLPP2 antibody that fits your needs. Choose from 1 of 10 PHLPP2 antibodies, which have been validated in experiments with 15 publications and 27 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the... Antibodies that detect PHLPP2 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and Immunoprecipitation. These antibodies target PHLPP2 in Human, Mouse and Rat samples. Our PHLPP2 polyclonal antibodies are developed in Rabbit and Goat. Find the PHLPP2 antibody that fits your needs. Choose from 1 of 10 PHLPP2 antibodies, which have been validated in experiments with 15 publications and 27 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt]

Synonyms

AI481772; C130044A18Rik; GTPase activating protein and VPS9 domains 1; KIAA0931; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP2; Phlppl; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B; RGD1562857

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PHLPP2 Antibodies

Target Information

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