PA5-29100 targets PLA2G4A in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29100 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 263 of Human PLA2G4A.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
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Protein Aliases: calcium-dependent phospholipid-binding protein; cPLA2; cPLA2-alpha; Cytosolic phospholipase A2; Lysophospholipase; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4
Gene Aliases: CPLA2; cPLA2-alpha; cPLA2alpha; PLA2G4; PLA2G4A