Recommended positive controls: Raji, NIH-3T3.
Predicted reactivity: Mouse (95%), Rat (95%), Rabbit (92%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
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Protein Aliases: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; Lysophospholipase; MGC126350; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Aliases: CPLA2; cPLA2-alpha; cPLA2alpha; PLA2G4; PLA2G4A
Molecular Function: phospholipase