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Invitrogen
PLCB1 Polyclonal Antibody
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FIGURE: 1 / 1
PLCB1 Antibody (PA5-78439) in WB
Western blot analysis of PLCB1 in various whole cell extracts (30 µg). Samples were incubated with PLCB1 polyclonal antibody (Product # PA5-78439) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG. Separated by 5% SDS-PAGE. Competitors antibody diluted at 1:100.
Product Details
PA5-78439
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of Bovine PLCB1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Amount
170 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: 293T, HeLa, HepG2
Predicted Reactivity: Mouse (90%), Rat (89%), Rhesus Monkey (91%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; Phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; triphosphoinositide phosphodiesterase; unnamed protein product
Gene Aliases: DEE12; EIEE12; KIAA0581; PI-PLC; PLC-154; PLC-beta-1; PLC-I; PLC154; PLCB1; PLCB1A; PLCB1B
UniProt ID: (Bovine) P10894, (Human) Q9NQ66
Entrez Gene ID: (Bovine) 287026, (Human) 23236
phosphatidylinositol phospholipase C activity
GTPase activator activity
calcium ion binding
lamin binding
phosphatidylinositol-4,5-bisphosphate binding
enzyme binding
phospholipase C activity
protein binding
calmodulin binding
phosphoric diester hydrolase activity
hydrolase activity
identical protein binding
phosphatidylinositol phospholipase C activity
phospholipase
G2/M transition of mitotic cell cycle
G-protein coupled acetylcholine receptor signaling pathway
glutamate receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
lipid catabolic process
cerebral cortex development
positive regulation of interleukin-12 production
interleukin-12-mediated signaling pathway
interleukin-15-mediated signaling pathway
positive regulation of embryonic development
positive regulation of GTPase activity
fat cell differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
insulin-like growth factor receptor signaling pathway
positive regulation of developmental growth
activation of meiosis involved in egg activation
interleukin-1-mediated signaling pathway
postsynaptic modulation of chemical synaptic transmission
regulation of retrograde trans-synaptic signaling by endocanabinoid
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of acrosome reaction
negative regulation of monocyte extravasation
positive regulation of CD24 biosynthetic process
lipid metabolic process
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
learning
memory
positive regulation of glycoprotein biosynthetic process
phosphatidylinositol catabolic process
positive regulation of insulin secretion
inositol trisphosphate metabolic process
response to monosaccharide
intracellular signal transduction
response to peptide hormone
phosphatidylinositol metabolic process
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol
regulation of fertilization
cellular response to fluoride
regulation of establishment of endothelial barrier
cellular response to vasopressin
cellular response to ionomycin
cellular response to glyceraldehyde
ligand-gated ion channel signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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