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The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; 3110043I21Rik; AI132408; EIEE12; inositoltrisphosphohydrolase; KIAA0581; mKIAA0581; monophosphatidylinositol phosphodiesterase; Phosphb; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C; phospholipase C beta 1; phospholipase C, beta 1; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta1; phospholipase C-beta-1; phospholipase C-beta-1a; phospholipase C-I; PI-PLC; PLC'1; PLC154; PLC-154; Plcb; PLCB1; PLCB1A; PLCB1B; PLCbeta1; PLC-beta-1; PLC-I; RATPHOSPHB; triphosphoinositide phosphodiesterase
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