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Product Details
26551-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Phospholipase C beta 1 Fusion Protein Ag24750 (1162-1216 aa encoded by BC069420) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.33 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: LEFVQEAMK GKISEDSNHG SAPLSLSSDP GKVNHKTPSS EELGGDIPGK EFDTPL (1162-1216 aa encoded by BC069420)
Target Information
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; phospholipase C-beta-1a; Phospholipase C-beta1; Phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; triphosphoinositide phosphodiesterase
Gene Aliases: 3110043I21Rik; AI132408; EIEE12; KIAA0581; mKIAA0581; Phosphb; PI-PLC; PLC'1; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; PLCB1; PLCB1A; PLCB1B; PLCbeta1; RATPHOSPHB
UniProt ID: (Human) Q9NQ66, (Rat) P10687, (Mouse) Q9Z1B3
Entrez Gene ID: (Human) 23236, (Rat) 24654, (Mouse) 18795
Molecular Function:
phospholipase
G2/M transition of mitotic cell cycle
signal transduction
G-protein coupled acetylcholine receptor signaling pathway
glutamate receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
memory
regulation of G-protein coupled receptor protein signaling pathway
lipid catabolic process
cerebral cortex development
positive regulation of interleukin-12 production
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-15-mediated signaling pathway
positive regulation of embryonic development
positive regulation of GTPase activity
inositol phosphate metabolic process
fat cell differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
phosphatidylinositol metabolic process
insulin-like growth factor receptor signaling pathway
positive regulation of developmental growth
activation of meiosis involved in egg activation
interleukin-1-mediated signaling pathway
regulation of fertilization
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of acrosome reaction
negative regulation of monocyte extravasation
positive regulation of CD24 biosynthetic process
learning
response to organonitrogen compound
response to monosaccharide
response to peptide hormone
oocyte maturation
mRNA processing
lipid metabolic process
cell adhesion
brain development
insulin receptor signaling pathway
erythrocyte differentiation
macrophage differentiation
positive regulation of sodium:proton antiporter activity
regulation of cell cycle
phosphatidylinositol phospholipase C activity
signal transducer activity
GTPase activator activity
calcium ion binding
protein binding
calmodulin binding
lamin binding
phosphatidylinositol-4,5-bisphosphate binding
enzyme binding
protein homodimerization activity
phosphoric diester hydrolase activity
hydrolase activity
Performance Guarantee
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