Immunogen sequence: NKKKSHKSSE GSGKKKLSEQ ASNTYSDSSS MFEPSSPGAG EADTESDDDD DDDDCKKSSM DEGTAGSEAM ATEEMSNLVN
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.
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Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; inositoltrisphosphohydrolase; KIAA0581; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; Phosphoinositide phospholipase C-beta-1; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; Phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; PLC154; triphosphoinositide phosphodiesterase
Gene Aliases: EIEE12; KIAA0581; PI-PLC; PLC-154; PLC-beta-1; PLC-I; PLC154; PLCB1; PLCB1A; PLCB1B
UniProt ID: (Human) Q9NQ66
Entrez Gene ID: (Human) 23236