Immunogen sequence: TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP IPLKRQSNVA APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDAL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.
RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis. RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA. Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, which suggests that multiple signaling pathways are involved in carrying out Pol I transcription. RPA40 and RPA16 are subunits of Pol I that associate with each other at an early stage of RNA polymerase I assembly. RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III). RPA40, RPA16 and RPA135 encode the three subunits of RNA polymerase I, respectively. RPA194 is the largest subunit of RNA Pol I and is not a component of Pol II and Pol III.
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Protein Aliases: CAT53; FB19PP1-binding protein of 114 kDa; HLA-C associated transcript 53; MHC class I region proline-rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; phosphatase nuclear targeting subunit; PNUTSPP1R10; PP1-binding protein of 114 kDa; PPP1R10; Protein FB19; protein phosphatase 1; protein phosphatase 1 regulatory subunit 10; protein phosphatase 1, regulatory (inhibitor) subunit 10; protein phosphatase 1, regulatory subunit 10; regulatory (inhibitor) subunit 10; regulatory subunit 10; Serine/threonine-protein phosphatase 1 regulatory subunit 10; testis tissue sperm-binding protein Li 67n
Gene Aliases: CAT53; FB19; p99; PNUTS; PP1R10; PPP1R10; R111
UniProt ID: (Human) Q96QC0
Entrez Gene ID: (Human) 5514