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Proteintech
PTPRS Polyclonal Antibody
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Product Details
29415-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
rPTPσ Fusion Protein Ag30152
Conjugate
Form
Liquid
Concentration
800 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein tyrosine phosphatase PTPsigma; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma
Gene Aliases: PTP-sigma; PTPRS; PTPSIGMA; R-PTP-S; R-PTP-sigma
UniProt ID: (Human) Q13332
Entrez Gene ID: (Human) 5802
protein dephosphorylation
cell adhesion
signal transduction
negative regulation of neuron projection development
spinal cord development
cerebellum development
hippocampus development
cerebral cortex development
corpus callosum development
negative regulation of axon extension
negative regulation of interferon-alpha production
negative regulation of interferon-beta production
negative regulation of toll-like receptor 9 signaling pathway
peptidyl-tyrosine dephosphorylation
negative regulation of collateral sprouting
negative regulation of axon regeneration
modulation of synaptic transmission
synapse organization
negative regulation of dendritic spine development
establishment of endothelial intestinal barrier
regulation of postsynaptic density assembly
trans-synaptic signaling
synaptic membrane adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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