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Invitrogen
RASA3 Polyclonal Antibody
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Product Details
PA5-75516
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 290-335 of Human RASA3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Human GAP1-InsP4 BP, also designated Ras p21 protein activator (GTPase-activating protein) 3 [Ins(1,3,4,5)P4-binding protein], is an 829-amino acid protein that binds phospholipids in both a calcium-dependent and -independent manner. GAP1, one of the Ras GTPase-activating protein families, comprises four distinct genes, including GAP1(m), GAP1-InsP4 BP, MRASAL (murine Ras GTPase-activating-like) and KIAA0538. This family contains an N-terminal tandem C2 domain, a GAP-related domain and a C-terminal pleckstrin homology (PH) domain. The PH domains of GAP1-InsP4 BP are essential for membrane targeting via binding of specific phospholipids. Following agonist-stimulated PtdIns(3,4,5)P(3) production, group I family PH domain containing proteins like GAP1-InsP4 BP specifically bind inositol phosphates, which are subsequently targeted to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GAP1(IP4BP); GAP1-InsP4 BP; GapIII; GAPIII activator 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; R-Ras gap; R-Ras GTP activating protein; R-ras GTPase activating protein; R-ras RTPase activating protein-3; Ras GTPase-activating protein 3; Ras GTPase-activating protein III; RP11-245B11.3; unnamed protein product
Gene Aliases: AI326412; C86362; E130011G04; GAP1IP4BP; GAPIII; R-ras gap; RASA3; scat
UniProt ID: (Human) Q14644, (Mouse) Q60790, (Rat) Q9QYJ2
Entrez Gene ID: (Human) 22821, (Mouse) 19414, (Rat) 29372
response to stress
signal transduction
platelet activation
intracellular signal transduction
negative regulation of Ras protein signal transduction
regulation of intracellular signal transduction
cellular response to heat
regulation of GTPase activity
positive regulation of GTPase activity
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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