RASA3 Antibodies

Target Information

Human GAP1-InsP4 BP, also designated Ras p21 protein activator (GTPase-activating protein) 3 [Ins(1,3,4,5)P4-binding protein], is an 829-amino acid protein that binds phospholipids in both a calcium-dependent and -independent manner. GAP1, one of the Ras GTPase-activating protein families, comprises four distinct genes, including GAP1(m), GAP1-InsP4 BP, MRASAL (murine Ras GTPase-activating-like) and KIAA0538. This family contains an N-terminal tandem C2 domain, a GAP-related domain and a C-terminal pleckstrin homology (PH) domain. The PH domains of GAP1-InsP4 BP are essential for membrane targeting via binding of specific phospholipids. Following agonist-stimulated PtdIns(3,4,5)P(3) production, group I family PH domain containing proteins like GAP1-InsP4 BP specifically bind inositol phosphates, which are subsequently targeted to the plasma membrane.

Synonyms

AI326412; C86362; E130011G04; GAP1(IP4BP); GAP1-InsP4 BP; GAP1IP4BP; GAPIII; GAPIII activator 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; ras GTPase-activating protein 3; Ras GTPase-activating protein III; RAS p21 protein activator 3; Rasa3; RP11-245B11.3; R-Ras gap; R-Ras GTP activating protein; R-ras GTPase activating protein; R-ras RTPase activating protein-3; scat