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Invitrogen
RNASE7 Monoclonal Antibody (CL0224)
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Product Details
MA5-24591
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
CL0224
Immunogen
Recombinant protein fragment of Human RNASE7 (Product #RP-88942).
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Amount
110 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KGMTSSQWFK IQHMQPSPQA CNSAMKNINK HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS HGPVSLTMCK LTSGKYPNCR YKEKRQNKSY VVACKPPQKK DSQQFHLVPV HLDRV
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 56%.
Binds to an epitope located within the peptide sequence KGMTSSQWFKIQHMQ as determined by overlapping synthetic peptides.
Target Information
The RNASE7 gene encodes a ribonuclease enzyme characterized by its potent ribonucleolytic activity and antimicrobial properties. It is part of the RNase A superfamily, featuring eight conserved cysteines and a catalytic histidine-lysine-histidine triad. RNase 7 is expressed in various somatic tissues, including the liver, kidney, skeletal muscle, and heart, and is prominently found in the stratum corneum of human skin. Its role is crucial in innate immune defense, assisting in the high resistance of human skin against infections. The expression of RNASE7 can be significantly induced by pro-inflammatory cytokines such as interferon-gamma, interleukin 1 beta, and to a lesser extent by tumor necrosis factor-a. This induction highlights its role in immune responses. Beyond its antimicrobial activity, RNase 7 has been shown to play a role in translating self-nucleic acids into TLR9 activators, influencing the DNA-mediated activation of immune cells like keratinocytes. These functions underscore RNASE7's significance in both maintaining skin barrier function and modulating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ribonuclease 7; ribonuclease, RNase A family, 7; RNase 7; SAP-2; Skin-derived antimicrobial protein 2; unnamed protein product
Gene Aliases: RAE1; RNASE7; UNQ2516/PRO6006
UniProt ID: (Human) Q9H1E1
Entrez Gene ID: (Human) 84659
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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