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RORG Polyclonal Antibody

View all (31) ROR gamma antibodies

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RORG Polyclonal Antibody

Product Details

BS-6217R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human RORG, amino acids 415-518.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; RORC; Thymus orphan receptor; TOR; unnamed protein product

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Gene Aliases: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR

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UniProt ID: (Human) P51449, (Mouse) P51450

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Entrez Gene ID: (Human) 6097, (Rat) 368158, (Mouse) 19885

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding oxysterol binding zinc ion binding sequence-specific DNA binding metal ion binding transcription factor activity, direct ligand regulated sequence-specific DNA binding sequence-specific double-stranded DNA binding molecular_function steroid hormone receptor activity transcription coactivator binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter xenobiotic metabolic process circadian rhythm regulation of gene expression regulation of glucose metabolic process regulation of steroid metabolic process intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol T-helper cell differentiation positive regulation of circadian rhythm regulation of fat cell differentiation positive regulation of transcription, DNA-templated rhythmic process lymph node development Peyer's patch development adipose tissue development negative regulation of thymocyte apoptotic process T-helper 17 cell differentiation transcription, DNA-templated steroid hormone mediated signaling pathway protein phosphorylation multicellular organism development cell differentiation interleukin-17 production T cell differentiation in thymus regulation of gamma-delta T cell differentiation alpha-beta T cell differentiation mucosal-associated lymphoid tissue development regulation of transcription involved in cell fate commitment
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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