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Proteintech
SAP18 Polyclonal Antibody
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Product Details
13841-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SAP18 Fusion Protein Ag4795 (1-153 aa encoded by BC030836)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAVESRVTQ EEIKKEPEKP IDREKTCPLL LRVFTTNNGR HHRMDEFSRG NVPSSELQIY TWMDATLKEL TSLVKEVYPE ARKKGTHFNF AIVFTDVKRP GYRVKEIGST MSGRKGTDDS MTLQSQKFQI GDYLDIAITP PNRAPPTSGR MRPY (1-153 aa encoded by BC030836)
Target Information
SAP18 is involved in histone acetylation, which plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 18 kDa Sin3-associated polypeptide; 2HOR0202; cell growth inhibiting protein 38; Cell growth-inhibiting gene 38 protein; cell growth-inhibiting protein 38; histone deacetlyase complex subunit SAP18; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, 18kDa; sin3-associated polypeptide, p18; Sin3A associated protein 18kDa; Sin3A-associated protein, 18kDa
Gene Aliases: 2HOR0202; C530046K05Rik; D11Ertd539e; EMegR4; GIG38; SAP18; SAP18P; Sinbp1
UniProt ID: (Human) O00422, (Mouse) O55128
Entrez Gene ID: (Human) 10284, (Mouse) 20220, (Rat) 290284
regulation of alternative mRNA splicing, via spliceosome
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mRNA processing
RNA splicing
histone deacetylation
positive regulation of apoptotic process
negative regulation of mRNA splicing, via spliceosome
negative regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
chromatin modification
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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