|Tested species reactivity||Bovine, Dog, Human, Mouse, Pig|
|Host / Isotype||Goat / IgG|
|Immunogen||synthetic peptide GEKNGDAKTFWME (Human) (N terminal).|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.3-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-31091 detects SETDB2 from human samples.
PA1-31091 has been successfully used in Western blot applications.
The PA1-31091 immunogen is: Synthetic peptide: GEKNGDAKTFWME (Human) (N terminal).
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.