Immunogen sequence: TDFDFLKVI GKGSFGKVLL AKRKLDGKFY AVKVLQKKIV LNRKEQKHIM AERNVLLKNV KHPFLVGLHY SFQTTEKLYF VLDFVNGGEL FFHLQRERSF PEHRARFYAA EIASALGYLH SIKIVYRDLK PENILLDSVG HVVLTDFGLC KEGIAISDTT TTFCGTPEYL APEVIRKQPY DNTVDWWCLG AVLYEMLYGL PPFYCRDVAE MYDNILHKPL SLRPGVSLTA WSILEELLEK DRQNRLGAKE DFLEIQNHPF FESLSWADLV QKKIPPPFNP NVAGPDDIRN FDTAFTEETV PYSVCVSSDY SIVNASVLEA DDAFVGFSYA PPSEDLFL (160-496 aa encoded by BC015326)
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: Cytokine-independent survival kinase; DKFZp781N0293; Serine/threonine-protein kinase Sgk3; serum/glucocorticoid regulated kinase 3; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like
Gene Aliases: 2510015P22Rik; A330005P07Rik; CISK; fy; fz; SGK2; SGK3; SGKL
Molecular Function: non-receptor serine/threonine protein kinase