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Invitrogen
SHISA7 Polyclonal Antibody
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Product Details
PA5-63631
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SHISA7. Recombinant protein control fragment (Product #RP-101586).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
The SHISA7 gene encodes a member of the Shisa family proteins, which are involved in the regulation of signaling pathways critical for embryonic development and cellular communication. SHISA7 is particularly influential in modulating synaptic transmission in the central nervous system. It plays a key role in regulating the surface expression and activity of AMPA-type glutamate receptors, which are crucial for fast excitatory neurotransmission and synaptic plasticity in the brain. By controlling the trafficking and localization of these receptors, SHISA7 impacts synaptic strength and neuronal excitability, affecting learning, memory, and other cognitive functions. The functional regulation by SHISA7 of AMPA receptors can have implications for neuropsychiatric disorders, where dysregulation of synaptic transmission is a common feature. Understanding SHISA7's role in synaptic modulation could lead to insights into the mechanisms underlying cognitive processes and the development of therapeutic strategies for neurological conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKAMP59; Cystine-knot AMPAR modulating protein of 59 kDa; GABA(A) receptor auxiliary subunit Shisa7; hCG_2039146; Protein shisa-6-like; Protein shisa-7; shisa homolog 7; unnamed protein product; UPF0626 protein A
Gene Aliases: CKAMP59; SHISA7
UniProt ID: (Human) A6NL88
Entrez Gene ID: (Human) 729956
gamma-aminobutyric acid signaling pathway
memory
gamma-aminobutyric acid receptor clustering
regulation of GABA-A receptor activity
positive regulation of long-term synaptic potentiation
regulation of AMPA glutamate receptor clustering
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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