|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||2 ug/ml|
|Western Blot (WB)||1 ug/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||See 2 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
The immunogenic sequence is common to all three known ST2 isoforms.
A suggested positive control is 293 cell lysate.
PA5-20077 can be used with blocking peptide PEP-0195.
ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DER4, Fit-1, Ly84, ST2L, St2, St2-rs1, T1, T1/ST2; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Lymphocyte antigen 84; Protein ST2; Protein T1
Gene Aliases: DER4; FIT-1; IL1RL1; IL33R; Ly84; ST2; St2-rs1; ST2L; ST2V; Ste2; T1; T1/ST2
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