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OriGene
ELL Monoclonal Antibody (OTI1B5), TrueMAB™
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FIGURE: 1 / 1
ELL Antibody (TA810828) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ELL (RC208258, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ELL. (1:2. Positive lysates LY416583 (100 µg) and LC416583 (20 µg) can be purchased separately from OriGene.
Product Details
TA810828
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1B5
Immunogen
Human recombinant protein fragment corresponding to amino acids 302-621 of human ELL produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Eleven-nineteen lysine-rich leukemia protein; ELL; ELL gene (11-19 lysine-rich leukemia gene); ELL/KMT2A fusion protein; elongation factor RNA polymerase II; KMT2A/ELL fusion protein; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; unnamed protein product
Gene Aliases: C19orf17; ELL; ELL1; MEN; PPP1R68
UniProt ID: (Human) P55199
Entrez Gene ID: (Human) 8178
in utero embryonic development
transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
positive regulation of transcription elongation from RNA polymerase II promoter
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
positive regulation of transcription from RNA polymerase III promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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