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OriGene
MAP2 Monoclonal Antibody (OTI3E2), TrueMAB™
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FIGURE: 1 / 1
MAP2 Antibody (TA813554) in WB
Western blot analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Cat # PS100001, Left lane) or pCMV6-ENTRY MAP2 (Cat # RC216775, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and blotted with anti-MAP2 antibody (Cat # TA813554)(1:1000).
Product Details
TA813554
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3E2
Immunogen
Human recombinant protein fragment corresponding to amino acids 1507-1827 of human MAP2 (NP_002365) produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Dilute in PBS (pH7.3) if necessary. Stable for 12 months from date of receipt.
Target Information
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC091465.1; DKFZp686I2148; MAP 2; MAP-2; map-2a; map2ab; microtubule associated protein 2; Microtubule-associated protein 2; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
Gene Aliases: G1-397-34; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Mtap-2; Mtap2; repro4
UniProt ID: (Human) P11137, (Mouse) P20357
Entrez Gene ID: (Human) 4133, (Mouse) 17756
microtubule bundle formation
axonogenesis
dendrite development
cellular response to organic substance
microtubule cytoskeleton organization
central nervous system neuron development
negative regulation of axon extension
regulation of microtubule polymerization
negative regulation of microtubule polymerization
neuron projection development
regulation of protein localization
dendrite morphogenesis
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
positive regulation of anterograde synaptic vesicle transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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